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Mishra, Shanti Bhushan
- Antiulcer Study of Capparis zeylanica Extract on Gastric Secretions and Phenylbutazone Induced Chronic Ulceration in Experimental Animals
Authors
1 United Institute of Pharmacy, Naini, Allahabad - 211010, UP, IN
2 Department of Pharmaceutical Science, SHUATS, Allahabad - 211007, UP, IN
3 Department of Pharmacy, MLN Medical College, Allahabad - 211001, UP, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 2 (2017), Pagination: 126-133Abstract
Purpose: The objective of the study was to investigate the possible effects of 50% ethanolic extract of Capparis zeylanica (CZE) on gastric secretion and Phenylbutazone ulcer in rats. Approach: Twenty four adult male rats were used in this study (four groups) and several parameters were determined to assess any degree of protection. The ulceration was induced by Phenylbutazone at a dose of 100 mg/kg b.w.
Findings: Phenylbutazone toxicity induced + CZE treated rats showed a significant decrease (p > 0.001) in volume of gastric juice, free and total acidity, pepsin concentration and acid output with a significant increase (p > 0.001) in pH compared to Phenylbutazone toxicity induced rats. Phenylbutazone caused a significant decrease (p > 0.001) in TC:P with a concomitant increase (p > 0.001) in protein and DNA. After treatment of CZE in rats, a significant increase (p > 0.001) in the carbohydrate concentration in terms of TC:P ratio and significantly lowered (p > 0.001) protein concentration in gastric juice was observed. CZE tended to increase mucin activity in Phenylbutazone + CZE group.
Conclusion: It can be concluded that CZE imparted a protective action against phenylbutazone induced chronic ulcer in rats.
Keywords
Antiulcer, Capparis zeylanica, Phenylbutazone, Plant extract, Ranitidine.Full Text
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- Antiulcer Potential of Cucumis melo Var. Momordica (Roxb.), Duthie & Fuller Fruits in Experimental Animal
Authors
1 Department of Pharmaceutical Chemistry, United Institute of Pharmacy, Naini, Allahabad, IN
2 Department of Pharmaceutical Sciences, SHUATS, Allahabad, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 3 (2017), Pagination: 218-223Abstract
Purpose: This study was aimed to evaluate the antiulcer potential of Cucumis melo var. momordica (Roxb.) Duthie&Fuller, fruits.
Methodology: Ethanol and pylorus ligation induced ulcer methods were used in rats for the study. The aqueous and ethanolic extracts (200 and 400 mg/kg body weight) were administered orally and effects on volume of gastric secretions, ulcer index, total and free acidity were evaluated.
Findings: A significant dose dependent reduction (P < 0.05) in the acid parameters like ulcer index, gastric volume, free and total acidity and elevation in pH were observed after treatment with 200 and 400 mg/kg extracts in Pylorus ligation and ethanol-induced ulcer models.This reduction in acid-secretary parameters and ulcer score suggesting that acid inhibition accelerates ulcer healing.
Conclusion: Based on our findings, we presume that the anti-secretary properties of both extracts were responsible for its anti-ulcer potency. These findings suggest the potential for use of Cucumis melo extract as an adjuvant in the treatment of gastric ulcer.
Keywords
Antiulcer, Cucumis melo Var. Momordica (Roxb.) Duthie & Fuller, Ethanolic Extract Pylorus Ligation.Full Text
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